Author

D. Angeletti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. W. Yewdell· 3 shared A. A. Sarshad· 2 shared C. Fernandez· 2 shared C. Lebrero-Fernandez· 2 shared H. D. Hickman· 2 shared H.-C. Huang· 2 shared I. Kosik· 2 shared I. Nowak· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersImmunology

J. W. Yewdell

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Author profile →

6 papers

Recent·Most cited

Nuclear RNAi Modulates Influenza A Virus Infectivity By Downregulating Type-I Interferon Response

H.-C. Huang, I. Nowak, V. Lobo, D. F. Besavilla, K. Schon, J. O. Westholm, C. Fernandez, A. A. Patel, C. Wiel, V. I. Sayin, D. G. Anastasakis, D. Angeletti, A. A. Sarshad

This study shows that influenza A virus exploits nuclear RNAi by inducing AGO2 accumulation and silencing type-I interferon genes, and that arsenic trioxide can counteract this effect.

bioRxiv · Mar 7, 2024 · PreprintBiochemistry

Loss of Lamin A leads to the nuclear translocation of AGO2 and compromised RNA interference

V. Lobo, I. Nowak, C. Fernandez, A. I. Correa Muler, J. O. Westholm, H.-C. Huang, I. Fabrik, H. T. Huynh, E. Shcherbinina, M. Poyraz, A. Hartlova, D. Benhalevy, D. Angeletti, A. A. Sarshad

This study shows that loss of Lamin A causes AGO2 to move into the nucleus, impairing RNAi and increasing oncogenic miRNA expression in cancer cells.

bioRxiv · Jun 5, 2023Biochemistry

Tr1 cell-mediated protection against autoimmune disease by intranasal administration of a fusion protein targeting cDC1 cells

C. Hansson, C. Lebrero-Fernandez, K. Schön, D. Angeletti, N. Lycke

The paper develops a tolerogenic fusion protein that reduces autoimmune disease symptoms by inducing Tr1 cells and altering cDC1 gene expression via IL-27 signaling.

bioRxiv · Apr 11, 2023Immunology

Single cell BCR and transcriptome analysis after respiratory virus infection reveals spatiotemporal dynamics of antigen-specific B cell responses.

N. R. Mathew, J. K. Jayanthan, I. Smirnov, J. L. Robinson, H. Axelsson, S. S. Nakka, A. Emmanouilidi, P. Czarnewski, W. T. Yewdell, C. Lebrero-Fernandez, V. Bernasconi, A. M. Harandi, N. Lycke, N. Borcherding, J. W. Yewdell, , D. Angeletti

The paper analyzes single-cell BCR and transcriptome data from influenza-infected mice to reveal organ-specific B cell dynamics and clonal responses.

bioRxiv · Aug 24, 2020Immunology

Neuraminidase Inhibition Contributes to Influenza A Virus Neutralization by Anti-Hemagglutinin Stem Antibodies

I. Kosik, D. Angeletti, J. S. Gibbs, M. Angel, K. Takeda, M. Kosikova, V. Nair, H. D. Hickman, H. Xie, C. C. Brooke, J. W. Yewdell

This study shows anti-HA stem antibodies neutralize influenza A virus by inhibiting neuraminidase activity, with implications for therapeutic synergy with NA inhibitors.

bioRxiv · Aug 22, 2018Microbiology

Outflanking Immunodominance to Target Subdominant Broadly Neutralizing Epitopes

D. Angeletti, I. Kosik, W. T. Yewdell, C. M. Boudreau, V. V. Mallajosyula, M. Chambers, M. Prabhakaran, H. D. Hickman, A. B. McDermott, G. Alter, J. Chaudhuri, J. W. Yewdell

This study shows that immunodominance in influenza HA can be overcome by targeting the conserved stem through specific immunization strategies.

bioRxiv · Jun 14, 2018Immunology