Hypoxia-induced epigenetic silencing of polo-like kinase 2 promotes fibrosis in atrial fibrillation
S. R. Kuenzel, K. Sekeres, S. Kaemmerer, T. Kolanowski, S. Meyer-Roxlau, C. Piorkowski, S. M. Tugtekin, S. Rose-John, X. Yin, M. Mayr, J. D. Kuhlmann, P. Wimberger, K. Gruetzmann, N. Herzog, J.-H. Kuepper, , A. El-Armouche
This study identifies hypoxia-induced epigenetic silencing of PLK2 and its role in promoting atrial fibrosis via OPN secretion in AF.
bioRxiv · Oct 17, 2018Pharmacology & Toxicology