X. Yin

Distinct Type 1 Immune Networks Underlie the Severity of Restrictive Lung Disease after COVID-19

The paper identifies distinct type 1 immune networks associated with varying severities of restrictive lung disease following COVID-19.

Role of 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-3 in Maintaining Redox Homeostasis and DNA Repair in Non-Small Cell Lung Cancers Under EGFR-Targeting Therapy

This study shows that inhibiting PFKFB3 enhances the effectiveness of EGFR-TKIs by disrupting metabolic adaptations and DNA repair in drug-tolerant lung cancer cells.

Enolase inhibitors as therapeutic leads for Naegleria fowleri infection

This paper shows that enolase inhibitors, specifically HEX, are effective against Naegleria fowleri by inhibiting its glycolytic pathway and extending survival in infected rodents.

Chlamydial protease-like activating factor targets SLC7A11 for degradation to induce ferroptosis and facilitate dissemination.

This study identifies CPAF-mediated degradation of SLC7A11 as a mechanism for Chlamydia-induced ferroptosis, promoting bacterial dissemination and suggesting therapeutic targeting.

DNA origami assembled spheroid for evaluating cytotoxicity and infiltration of chimeric antigen receptor macrophage (CAR-M)

This study evaluates the cytotoxicity and infiltration of CAR-M using 3D tumor spheroids assembled with DNA origami, showing enhanced invasion and killing capacity in 3D models.

Mitochondria possess a large, non-selective ionic current that is enhanced during cardiac injury.

The paper identifies a large, non-selective ionic current in mitochondria, called LUNA, which increases during cardiac injury and is inhibited by amiloride.

Utility of T1 mapping and T2 mapping for non-invasive assessment of liver fibrosis: preclinical results

This study evaluates T1 and T2 mapping for assessing liver fibrosis in mice, finding they correlate with fibrosis stages and collagen/protein markers.

Novel Epidermal Oxysterols Function as Alarm Substances in Zebrafish

This study identifies two novel oxysterol sulfates in zebrafish skin that function as alarm substances, inducing anti-predator behaviors and increasing cortisol levels at sub-nanomolar concentrations.

ARF6 as a novel activator of HIF-2alpha in pulmonary arterial hypertension

This study identifies ARF6 as a novel activator of HIF-2alpha in pulmonary arterial hypertension and shows that the antibiotic CTC inhibits this pathway.

Myeloid-mesenchymal crosstalk drives Arg1-dependent profibrotic metabolism via ornithine in lung fibrosis

The paper identifies a myeloid-mesenchymal crosstalk pathway involving Arg1 and ornithine that drives profibrotic metabolism in lung fibrosis.

Plasma Glycomic Markers of Accelerated Biological Aging During Chronic HIV Infection

This study identifies glycomic alterations in HIV-positive individuals that correlate with accelerated aging and comorbidities, suggesting potential biomarkers for early detection.

Activation of Autoreactive Lymphocytes in the Lung by STING Gain-of-function Mutation Radioresistant Cells

This study shows that STING V154M mutation in non-hematopoietic cells activates autoreactive lymphocytes, leading to autoantibodies and lung inflammation in mice, mirroring SAVI in humans.

Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysis

This study uses single-cell spatial transcriptomics and optimal transport analysis to reveal therapy-induced changes in pancreatic cancer microenvironment interactions.

Protein interactome homeostasis through an N-recognin E3 ligase is a vulnerability in aneuploid cancer

The paper identifies UBR4 as a critical mediator of protein interactome homeostasis in aneuploid cancers, showing its inactivation causes proteotoxic stress and convergence of copy number and protein levels.

Metal-driven anaerobic oxidation of methane as an important methane sink in methanic cold seep sediments

The paper investigates metal-driven anaerobic methane oxidation in cold seep sediments, finding that Fe-AOM and Mn-AOM contribute ~3% to methane removal.

Multi-omics of the gut microbial ecosystem in the immunotherapy resistance in microsatellite instability-high gastrointestinal cancer patients

The paper uses multi-omics data to identify gut microbiome and metabolite markers of immunotherapy resistance in MSI-H/dMMR gastrointestinal cancer patients and develops a predictive model with 0.83 accuracy.

Experimental study of modified human tendon stem cells to promote graft ligamentation and tendon-bone healing after anterior cruciate ligament reconstruction

This study modifies human tendon stem cells to enhance graft ligamentation and tendon-bone healing after ACL reconstruction, showing improved recovery in animal models.

Site-directed placement of three-dimensional DNA origami

This paper describes a method for 3D positioning of DNA origami structures on nano-patterned substrates, enabling scalable and versatile fabrication of complex 3D surfaces.

The metabolite alpha-ketobutyrate increases health and life spans by activating AMPK

This paper shows that alpha-ketobutyrate extends lifespan and healthspan in C. elegans and mice by activating AMPK through MACF1/VAB-10.

Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity

This study uses human blood vessel organoids to show that CTGF is critical for maintaining microvascular integrity under metabolic stress.

CARD8 negatively regulates NLRP1 inflammasome activation level by interaction with NLRP1

This study shows that the T60 variant of CARD8 inhibits NLRP1 inflammasome activation by interacting with NLRP1 and preventing inflammasome assembly.

Persister state-directed transitioning and vulnerability in melanoma

This study identifies a compound that induces a persister state in melanoma cells, promoting differentiation and sensitizing them to a prodrug, offering a dual-target strategy for treatment.

The majority of microorganisms in gas hydrate bearing subseafloor sediments ferment macromolecules

This study identifies fermentation of macromolecules as the dominant energy source for microorganisms in gas hydrate-bearing subseafloor sediments.

TME induced TRAIL secretion from engineered macrophages for anti-tumor therapy

This study engineers macrophages to inducibly secrete TRAIL in response to the tumor microenvironment, showing improved anti-tumor effects and reduced side effects in preclinical models.

PPAR-γ activation promotes xenogenic bioroot regeneration by attenuating the xenograft induced-oxidative stress

This study shows that PPAR-γ activation with rosiglitazone reduces oxidative stress and promotes xenograft regeneration in a dental follicle cell model.

LIPA-driven hydrolysis of cholesteryl arachidonate promotes cancer metastasis via NF-κB

This study identifies LIPA as a key regulator of CE hydrolysis in cancer cells, showing that its inhibition suppresses metastasis via suppression of NF-κB signaling.

Earliest evidence for frugivory and seed dispersal by birds

This study identifies Jeholornis as the earliest known frugivorous bird, providing evidence for bird-mediated seed dispersal during the Early Cretaceous.

Lysine acetylation regulates antibiotic resistance in Escherichia coli

This study identifies acetylation as a regulatory mechanism in antibiotic resistance in E. coli, showing it negatively affects metabolism but positively influences motility, with PykF acetylation playing a key role.

Effects of sub-lethal single, simultaneous, and sequential abiotic stresses on phenotypic traits of Arabidopsis thaliana

This study examines how sub-lethal abiotic stresses affect 12 phenotypic traits in Arabidopsis thaliana, finding additive and interactive effects across different stress combinations and accessions.

EFHD1 ablation reduces cardiac mitoflash activation and protects cardiomyocytes from ischemia.

This study shows that EFHD1 deletion reduces mitochondrial Ca2+ overload and ROS production, protecting cardiomyocytes from ischemia-induced injury.