Author

S. Rose-John

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

H. A. Neubauer· 2 shared K. Trachtova· 2 shared M. Oberhuber· 2 shared M. Schlederer· 2 shared S. Huber· 2 shared S. Lagger· 2 shared S. Tangermann· 2 shared A. Bissell· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

H. A. Neubauer

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Author profile →

6 papers

Recent·Most cited

A maternal high-fat diet predisposes to infant lung disease via increased neutrophil-mediated IL-6 trans-signaling

B. Curren, T. Ahmed, R. B. Rashid, I. Sebina, M. A. A. Sikder, D. R. Howard, M. Alorro, M. A. Ullah, A. Bissell, M. M. Rahman, M. A. Pearen, G. A. Ramm, A. Varelias, S. Rose-John, P. O. Cuiv, , S. Phipps

This study shows that a maternal high-fat diet increases neonatal systemic inflammation and predisposes to infant lung disease via neutrophil-mediated IL-6 trans-signaling.

bioRxiv · Mar 13, 2024Immunology

Cell-autonomous GP130 activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment

C. Sternberg, T. Limberger, M. Raigel, K. Trachtova, M. Schlederer, D. Lindner, P. Kodajova, J. Yang, R. Ziegler, H. A. Neubauer, S. Dey, T. Redmer, S. Stoiber, V. Hejret, B. Tichy, , L. Kenner

This study shows that activating GP130 in prostate epithelial cells suppresses tumor growth through senescence and immune activation, suggesting a new therapeutic approach.

bioRxiv · Feb 11, 2024 · PreprintCancer Biology

STAT3 restricts prostate cancer metastasis and antiandrogen resistance by controlling LKB1/CREB signaling pathway

J. Pencik, C. Philippe, M. Schlederer, M. Pecoraro, S. Grund-Groeschke, W. J. Li, A. Tracz, I. Heidegger, S. Lagger, K. Trachtova, M. Oberhuber, E. Heitzer, O. Osman, H. A. Neubauer, B. Wingelhofer, , C. McKinney

This study identifies STAT3's role in restricting prostate cancer metastasis and antiandrogen resistance by regulating the LKB1/CREB signaling pathway in mouse models and human patients.

bioRxiv · Aug 25, 2022 · PreprintCancer Biology

Peripheral sgp130-mediated trans-signaling blockade induces obesity and insulin resistance in mice via PPARα suppression

T. Lanton, O. Levkovitch-Siany, S. Udi, J. Tam, R. Abramovich, S. Perles, E. Williams, J. Rachmilewitz, U. Mor, E. Elinav, D. Schmidt-Arras, A. Rehman, P. Rosenstiel, A. Giannou, S. Huber, , J. H. Axelrod

This study shows that blocking peripheral sgp130-mediated trans-signaling in mice causes obesity and insulin resistance by suppressing PPARα.

bioRxiv · Sep 24, 2020 · PreprintPhysiology

Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during periods of clinical latency

M. Werner-Klein, A. Grujovic, C. Irlbeck, M. Obradovic, M. Hoffmann, H. Koerkel-Qu, X. Lu, S. Treitschke, C. Koestler, C. Botteron, K. Weidele, C. Werno, B. Polzer, S. Kirsch, M. Guzvic, , C. A. Klein

The paper identifies IL6 trans-signaling as a mechanism supporting DCC survival and outgrowth during clinical latency, with microenvironmental dependencies and PIK3CA mutations linked to metastatic progression.

bioRxiv · May 28, 2020Cancer Biology

Hypoxia-induced epigenetic silencing of polo-like kinase 2 promotes fibrosis in atrial fibrillation

S. R. Kuenzel, K. Sekeres, S. Kaemmerer, T. Kolanowski, S. Meyer-Roxlau, C. Piorkowski, S. M. Tugtekin, S. Rose-John, X. Yin, M. Mayr, J. D. Kuhlmann, P. Wimberger, K. Gruetzmann, N. Herzog, J.-H. Kuepper, , A. El-Armouche

This study identifies hypoxia-induced epigenetic silencing of PLK2 and its role in promoting atrial fibrosis via OPN secretion in AF.

bioRxiv · Oct 17, 2018Pharmacology & Toxicology