Inhibiting endoplasmic reticulum stress decreases tumor burden in a mouse model for hepatocellular carcinoma.
N. Pavlovic, C. Calitz, K. Thanapirom, G. Mazza, K. Rombouts, P. Gerwins, F. Heindryckx
The paper shows that inhibiting IRE1 reduces tumor burden in a mouse HCC model by blocking stellate cell activation and tumor cell proliferation.
bioRxiv · Feb 20, 2020 · PreprintCancer Biology