Author

K. Tsuboyama

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Assay:proteomics· 2 Organism:E. coli· 1 Assay:protein structure· 1

Frequent Co-Authors

Y. Tomari· 2 shared A. Y. W. Lam· 1 shared E. Laine· 1 shared E. Morimoto· 1 shared G. J. Rocklin· 1 shared H. Tadakuma· 1 shared J. Chen· 1 shared J. Dauparas· 1 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiophysics

Y. Tomari

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3 papers

Recent·Most cited

Mega-scale experimental analysis of protein folding stability in biology and protein design

K. Tsuboyama, J. Dauparas, J. Chen, E. Laine, Y. Mohseni Behbahani, J. J. Weinstein, N. M. Mangan, S. Ovchinnikov, G. J. Rocklin

The paper introduces cDNA display proteolysis to measure protein folding stability for thousands of protein domains, revealing environmental factors, thermodynamic couplings, and evolutionary divergence in amino acid usage.

bioRxiv · Dec 6, 2022Biophysics

DNAJA2 and Hero11 mediate similar conformational extension and aggregation suppression of TDP-43

A. Y. W. Lam, K. Tsuboyama, H. Tadakuma, Y. Tomari

The paper investigates how DNAJA2 and Hero11 prevent TDP-43 aggregation by stabilizing its extended conformation using single-molecule FRET.

bioRxiv · Nov 15, 2022Biophysics

Fusion with heat-resistant obscure (Hero) proteins have the potential to improve the molecular property of recombinant proteins

E. Morimoto, K. Tsuboyama, Y. Tomari

This study shows that fusing recombinant proteins with Hero proteins improves their solubility and stability in bacterial expression systems.

bioRxiv · Mar 3, 2022Biochemistry