Author

J. J. Weinstein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Research Focus:protein design· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:dimensionality reduction· 1 Assay:electrophysiology· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

S. J. Fleishman· 2 shared A. Abi-Dargham· 1 shared A. Goldenzweig· 1 shared C. Huang· 1 shared C. Saikia· 1 shared E. Garcia-Ruiz· 1 shared E. Laine· 1 shared E. Reuveny· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

S. J. Fleishman

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Author profile →

4 papers

Recent·Most cited

One-shot design elevates functional expression levels of a voltage-gated potassium channel

J. J. Weinstein, C. Saikia, I. Karbat, A. Goldenzweig, E. Reuveny, S. J. Fleishman

The paper introduces mPROSS, an algorithm that improves the functional expression of membrane proteins through one-shot design, achieving up to 14-fold increase in current densities without altering single-channel activity.

bioRxiv · Dec 28, 2022Biochemistry

Mega-scale experimental analysis of protein folding stability in biology and protein design

K. Tsuboyama, J. Dauparas, J. Chen, E. Laine, Y. Mohseni Behbahani, J. J. Weinstein, N. M. Mangan, S. Ovchinnikov, G. J. Rocklin

The paper introduces cDNA display proteolysis to measure protein folding stability for thousands of protein domains, revealing environmental factors, thermodynamic couplings, and evolutionary divergence in amino acid usage.

bioRxiv · Dec 6, 2022Biophysics

Stable and functionally diverse versatile peroxidases by computational design directly from sequence

S. Barber-Zucker, V. Mindel, E. Garcia-Ruiz, J. J. Weinstein, M. Alcalde, S. J. Fleishman

The paper designs stable and functionally diverse versatile peroxidases using computational methods, showing improved expression and environmental tolerance compared to wild-type enzymes.

bioRxiv · Nov 25, 2021 · PreprintBiochemistry

Multi-Task Learning based 3-Dimensional Striatal Segmentation of MRI - a Multi-modal Objective Assessment

M. Serrano-Sosa, J. X. Van Snellenberg, J. Meng, K. Spuhler, J. J. Weinstein, A. Abi-Dargham, M. Slifstein, C. Huang

This paper applies multi-task learning to automate 3D striatal segmentation in MRI, achieving results comparable to manual segmentation with high Dice similarity and correlation metrics.

bioRxiv · Jul 13, 2020 · PreprintBioengineering