Age-related Impairment of Implant Osseointegration is Associated with Immune Activation and Suppression of Angiogenic, Notch, and Wnt Pathways
K. Turajane, G. Ji, Y. Chinenov, M. Chao, U. M. Ayturk, M. B. Greenblatt, L. B. Ivashkiv, M. P. G. Bostrom, X. Yang
This study identifies age-related downregulation of angiogenic, Notch, and Wnt pathways in peri-implant tissue, linked to immune activation and impaired osseointegration in aged mice.
bioRxiv · Dec 27, 2020 · PreprintImmunology