Author

L. B. Ivashkiv

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 6 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Assay:scRNA-seq· 4 Approach:statistical model· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:differential expression· 3

Frequent Co-Authors

K. Wei· 3 shared L. T. Donlin· 3 shared S. M. Goodman· 3 shared S. Raychaudhuri· 3 shared V. P. Bykerk· 3 shared A. Filer· 2 shared C. Rozo· 2 shared C. YANG· 2 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersImmunology

K. Wei

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Author profile →

7 papers

Recent·Most cited

CXCL4 signaling and gene induction in human monocytes

C. YANG, R. Yuan, B. Mishra, R. D. Bill, Y. Zhang, Y. Du, M. D. Ah Kioon, F. J. Barrat, L. B. Ivashkiv

This study investigates CXCL4 signaling in human monocytes, identifying NF-κB and TBK1-JNK pathways and a potential role for TLR4, while noting challenges in isolating CXCL4's effects from endotoxin contamination.

bioRxiv · Oct 26, 2022 · PreprintImmunology

Costimulation of TLR8 responses by CXCL4 in Human Monocytes Mediated by TBK1-IRF5 Signaling and Epigenomic Remodeling

C. YANG, M. Bachu, Y. Du, C. Brauner, R. Yuan, M. D. Ah Kioon, G. Chesi, F. J. Barrat, L. B. Ivashkiv

This study shows CXCL4 enhances TLR8 responses in human monocytes by promoting inflammatory gene transcription and IL-1β production through TBK1-IRF5 signaling and chromatin remodeling.

bioRxiv · Mar 28, 2022 · PreprintImmunology

Age-related Impairment of Implant Osseointegration is Associated with Immune Activation and Suppression of Angiogenic, Notch, and Wnt Pathways

K. Turajane, G. Ji, Y. Chinenov, M. Chao, U. M. Ayturk, M. B. Greenblatt, L. B. Ivashkiv, M. P. G. Bostrom, X. Yang

This study identifies age-related downregulation of angiogenic, Notch, and Wnt pathways in peri-implant tissue, linked to immune activation and impaired osseointegration in aged mice.

bioRxiv · Dec 27, 2020 · PreprintImmunology

Bone Marrow Stromal Cells in a Mouse Model of Implant Osseointegration

A. Vesprey, E. S. Suh, D. Goz Ayturk, X. Yang, M. Rogers, B. Sosa, Y. Niu, I. Kalajzic, L. B. Ivashkiv, M. P. G. Bostrom, U. M. Ayturk

The paper identifies bone marrow stromal cell populations that contribute to implant osseointegration in a mouse model using lineage tracing and single-cell RNA-seq.

bioRxiv · Aug 17, 2020 · PreprintCell Biology

HBEGF+ macrophages identified in rheumatoid arthritis promote joint tissue invasiveness and are reshaped differentially by medications

D. Kuo, J. Ding, I. Cohn, F. Zhang, K. Wei, D. Rao, C. Rozo, U. K. Sokhi, Accelerating Medicines Partnership RA/SLE Network, E. F. DiCarlo, M. B. Brenner, V. P. Bykerk, S. M. Goodman, S. Raychaudhuri, G. Rätsch, , L. T. Donlin

A newly identified human macrophage phenotype in RA promotes joint tissue invasiveness and shows variable responses to anti-inflammatory medications.

bioRxiv · Jan 31, 2019 · PreprintImmunology

High dimensional analyses of cells dissociated from cryopreserved synovial tissue

L. T. Donlin, D. A. Rao, K. Wei, K. Slowikowski, M. J. McGeachy, J. D. Turner, N. Meednu, F. Mizoguchi, M. Gutierrez-Arcelus, D. J. Lieb, J. Keegan, K. Muskat, J. Hillman, C. Rozo, E. Ricker, , M. B Brenner

This paper establishes a protocol for dissociating cryopreserved synovial tissue to obtain viable cells with preserved transcriptomes and surface markers, enabling high-dimensional analysis of rheumatoid arthritis pathology.

bioRxiv · Mar 19, 2018Immunology

Single Cell Transcriptomics And Flow Cytometry Reveal Disease-Associated Fibroblast Subsets In Rheumatoid Arthritis

F. Mizoguchi, K. Slowikowski, J. L. Marshall, K. Wei, D. A. Rao, S. K. Chang, H. N. Nguyen, E. H. Noss, J. D. Turner, B. E. Earp, P. E. Blazar, J. Wright, B. P. Simmons, L. T. Donlin, G. D. Kalliolias, , M. B. Brenner

The paper identifies disease-associated fibroblast subsets in rheumatoid arthritis using single-cell transcriptomics and flow cytometry, revealing subset-specific markers and functional differences.

bioRxiv · May 26, 2017Immunology