Author

K. U. Malik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:electrophysiology· 1

Frequent Co-Authors

C. Fernandez-Pena· 2 shared J. H. Jaggar· 2 shared M. D. Leo· 2 shared P. Singh· 2 shared A. Bernardelli· 1 shared A. Mata-Daboin· 1 shared C. E. Mackay· 1 shared D. Peixoto-Neves· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersPhysiology

C. Fernandez-Pena

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2 papers

Recent·Most cited

Vasodilators activate TMEM16A channels in endothelial cells to reduce blood pressure

A. Mata-Daboin, T. A. C. Garrud, C. Fernandez-Pena, D. Peixoto-Neves, M. D. Leo, A. Bernardelli, P. Singh, K. U. Malik, J. H. Jaggar

Vasodilators stimulate TRPV4 channels, leading to calcium-dependent activation of nearby TMEM16A channels in endothelial cells to produce arterial hyperpolarization, vasodilation, and reduced blood pressure.

bioRxiv · Jun 2, 2023 · PreprintPhysiology

A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation

C. E. Mackay, M. Floen, M. D. Leo, R. Hasan, C. Fernandez-Pena, P. Singh, K. U. Malik, J. H. Jaggar

This study shows that PC-1 and PC-2 form a complex in endothelial cells that mediates flow-induced vasodilation through Ca2+ influx and NOS activation.

bioRxiv · Oct 16, 2021Physiology