Combinatorial morphogenetic and mechanical cues to mimic bone development for defect repair
S. Herberg, A. M. McDermott, P. N. Dang, D. S. Alt, R. Tang, J. H. Dawahare, D. Varghai, J.-Y. Shin, A. McMillan, A. Dikina, F. He, Y. B. Lee, Y. Cheng, K. Umemori, P. C. Wong, , E. Alsberg
The paper demonstrates that engineered human mesenchymal stem cell condensations with dual BMP-2 and TGF-β1 promote functional healing of critical-sized femoral defects via endochondral ossification, with healing rate and extent dependent on in vivo mechanical environment.
bioRxiv · Feb 26, 2019Bioengineering