Author

D. S. Alt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:development & morphogenesis· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Organism:human· 1 Organism:mouse· 1 Assay:organoid / primary culture· 1 Assay:proteomics· 1

Frequent Co-Authors

E. Alsberg· 3 shared D. Varghai· 2 shared H. Park· 2 shared J. D. Boerckel· 2 shared J.-Y. Shin· 2 shared P. N. Dang· 2 shared R. Tang· 2 shared S. Herberg· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioengineering

E. Alsberg

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Author profile →

3 papers

Recent·Most cited

In situ cell condensation-based cartilage tissue engineering via immediately implantable high-density stem cell core and rapidly degradable shell microgels

S. J. Lee, O. Jeon, Y. B. Lee, D. S. Alt, A. Ding, R. Tang, E. Alsberg

This paper develops core/shell microgels for in situ cartilage tissue engineering, enabling immediate implantation and spontaneous fusion of cell condensates without prior in vitro culture.

bioRxiv · Apr 20, 2024 · PreprintBioengineering

Scaffold-free human mesenchymal stem cell construct geometry regulates long bone regeneration

S. Herberg, D. Varghai, D. S. Alt, P. N. Dang, H. Park, Y. Cheng, J.-Y. Shin, A. D. Dikina, J. D. Boerckel, M. W. Rolle, E. Alsberg

This study shows that scaffold-free human mesenchymal stem cell tubes, with specific geometry and morphogen presentation, enhance endochondral bone regeneration in critical-sized femoral defects compared to loose hMSC sheets.

bioRxiv · Sep 30, 2019Bioengineering

Combinatorial morphogenetic and mechanical cues to mimic bone development for defect repair

S. Herberg, A. M. McDermott, P. N. Dang, D. S. Alt, R. Tang, J. H. Dawahare, D. Varghai, J.-Y. Shin, A. McMillan, A. Dikina, F. He, Y. B. Lee, Y. Cheng, K. Umemori, P. C. Wong, , E. Alsberg

The paper demonstrates that engineered human mesenchymal stem cell condensations with dual BMP-2 and TGF-β1 promote functional healing of critical-sized femoral defects via endochondral ossification, with healing rate and extent dependent on in vivo mechanical environment.

bioRxiv · Feb 26, 2019Bioengineering