Determination of the molecular reach of the protein tyrosine phosphatase SHP-1
L. Clemens, M. Kutuzov, K. V. Bayer, J. Goyette, J. Allard, O. Dushek
This study measures the molecular reach of PD-1 tethered SHP-1 complexes and shows how tethering affects substrate accessibility and enzyme activity.
bioRxiv · Sep 4, 2020Biophysics