Author

J. Goyette

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Biophysics· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Organism:human· 3 Approach:statistical model· 3 Assay:fluorescence / live-cell microscopy· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

J. Allard· 3 shared K. Gaus· 3 shared O. Dushek· 3 shared P. A. van der Merwe· 3 shared E. M. Denham· 2 shared L. Clemens· 2 shared M. I. Barton· 2 shared R. L. Paterson· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiophysics

J. Allard

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Ligand requirements for immunoreceptor triggering

M. I. Barton, R. L. Paterson, E. M. Denham, J. Goyette, P. A. van der Merwe

This study investigates ligand requirements for NTR triggering by varying ligand length, mobility, and valency, finding that size-based segregation, not clustering or mechanical force, is more consistent with the kinetic-segregation model.

bioRxiv · Sep 11, 2023Immunology

High-fidelity 3D live-cell nanoscopy through data-driven enhanced super-resolution radial fluctuation

R. F. Laine, H. S. Heil, S. Coelho, J. Nixon-Abell, A. Jimenez, T. Galgani, A. Stubb, G. Follain, J. Goyette, S. Webster, S. Culley, G. Jacquemet, B. Hajj, C. Leterrier, R. Henriques

This paper introduces eSRRF, an enhanced super-resolution imaging method that improves image fidelity and extends to 3D imaging using multi-focus microscopy.

bioRxiv · Apr 7, 2022Biophysics

Determination of the molecular reach of the protein tyrosine phosphatase SHP-1

L. Clemens, M. Kutuzov, K. V. Bayer, J. Goyette, J. Allard, O. Dushek

This study measures the molecular reach of PD-1 tethered SHP-1 complexes and shows how tethering affects substrate accessibility and enzyme activity.

bioRxiv · Sep 4, 2020Biophysics

Clustering of CD3ζ is sufficient to initiate T cell receptor signaling

Y. Ma, Y. J. Lim, A. Benda, J. Goyette, K. Gaus

This study shows that clustering of CD3ζ chains alone can initiate TCR signaling, including phosphorylation and calcium flux, in reconstituted cells.

bioRxiv · Feb 17, 2020 · PreprintImmunology

Regulated unbinding of ZAP70 at the T cell receptor by kinetic avidity

J. Goyette, D. Depoil, Z. Yang, S. A. Isaacson, J. Allard, P. A. van der Merwe, K. Gaus, M. Dustin, O. Dushek

The paper shows that ZAP70 unbinding from TCR is regulated by kinetic avidity, allowing both signal fidelity and reversibility in T cell responses.

bioRxiv · Feb 12, 2020 · PreprintImmunology

The Influence of Molecular Reach and Diffusivity on the Efficacy of Membrane-Confined Reactions

Y. Zhang, L. Clemens, J. Goyette, J. Allard, O. Dushek, S. A. Isaacson

The paper studies how molecular reach and diffusivity affect reaction efficacy in membrane-confined systems, showing that increasing reach can enhance or reduce efficacy depending on diffusion rates.

bioRxiv · Apr 7, 2019Biophysics

A generic cell surface ligand system for studying cell-cell recognition

E. M. Denham, M. I. Barton, S. M. Black, M. J. Bridge, B. de Wet, R. L. Paterson, P. A. van der Merwe, J. Goyette

This paper introduces a generic cell surface ligand system to manipulate ligand density, valency, dimensions, and affinity for studying cell-cell recognition.

bioRxiv · Feb 11, 2019Immunology

Conformational states control Lck switching between free and confined diffusion modes in T cells

G. Hilzenrat, E. Pandzic, Z. Yang, D. J. Nieves, J. Goyette, J. Rossy, K. Gaus

This study shows that Lck's conformational states determine its diffusive behavior in T cells, with open conformations leading to confined diffusion and closed conformations allowing free diffusion.

bioRxiv · Oct 18, 2018Immunology