Author

L. Clemens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

O. Dushek· 3 shared J. Allard· 2 shared J. Goyette· 2 shared J. F. Allard· 1 shared K. V. Bayer· 1 shared M. Kutuzov· 1 shared S. A. Isaacson· 1 shared Y. Zhang· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 18 mutual co-author links

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3 shared papersBiophysics

O. Dushek

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3 papers

Recent·Most cited

Intrinsic disorder in the T cell receptor creates cooperativity and controls ZAP70 binding

L. Clemens, O. Dushek, J. F. Allard

This paper uses simulations to show how intrinsic disorder in T cell receptor chains leads to nonlinear signaling through entropy changes, affecting ZAP70 binding and cooperativity.

Biophysical Journal · Jan 1, 2021Peer-reviewedBiophysics

Determination of the molecular reach of the protein tyrosine phosphatase SHP-1

L. Clemens, M. Kutuzov, K. V. Bayer, J. Goyette, J. Allard, O. Dushek

This study measures the molecular reach of PD-1 tethered SHP-1 complexes and shows how tethering affects substrate accessibility and enzyme activity.

bioRxiv · Sep 4, 2020Biophysics

The Influence of Molecular Reach and Diffusivity on the Efficacy of Membrane-Confined Reactions

Y. Zhang, L. Clemens, J. Goyette, J. Allard, O. Dushek, S. A. Isaacson

The paper studies how molecular reach and diffusivity affect reaction efficacy in membrane-confined systems, showing that increasing reach can enhance or reduce efficacy depending on diffusion rates.

bioRxiv · Apr 7, 2019Biophysics