Author

K. V. Ledwitch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

J. Meiler· 2 shared E. F. McDonald· 1 shared E. N. N. Okwei· 1 shared G. Kuenze· 1 shared H. L. Darling· 1 shared I. Coin· 1 shared J. A. Selvasingh· 1 shared J. R. Mckinney· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiophysics

J. Meiler

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2 papers

Recent·Most cited

Dark nanodiscs as a model membrane for evaluating membrane protein thermostability by differential scanning fluorimetry

J. A. Selvasingh, E. F. McDonald, J. R. Mckinney, K. V. Ledwitch, J. Meiler

This paper introduces a method using dark nanodiscs and nanoDSF to measure membrane protein thermostability, showing a biphasic unfolding pattern for DsbB with two distinct melting temperatures.

bioRxiv · May 8, 2023 · PreprintBiophysics

Pseudocontact shift NMR data obtained from a non-canonical amino acid-linked lanthanide tag improves integral membrane protein structure prediction

K. V. Ledwitch, G. Kuenze, K. Larochelle, E. N. N. Okwei, L. Pankewitz, S. Ganguly, H. L. Darling, I. Coin, J. Meiler

The paper improves integral membrane protein structure prediction by integrating paramagnetic NMR restraints with RosettaNMR, achieving better model accuracy and sampling for DsbB.

bioRxiv · Sep 14, 2022 · PreprintBiophysics