E. F. McDonald

Ribosomal Frameshifting Selectively Modulates the Assembly, Function, and Pharmacological Rescue of a Misfolded CFTR Variant

This paper identifies an RNA structure in the CFTR transcript that promotes ribosomal frameshifting and premature termination, enhancing the function and pharmacological rescue of the misfolded {Delta}F508 CFTR variant.

The proteostasis interactomes of trafficking-deficient KV11.1 variants associated with Long QT Syndrome and pharmacological chaperone rescue

The paper identifies proteostasis interactomes of trafficking-deficient KV11.1 variants and shows pharmacological chaperone rescue of proteostasis network alterations in LQTS-associated variants.

Site-Specific Crosslinking Reveals Phosphofructokinase-L Inhibition Drives Self-Assembly and Attenuation of Protein Interactions

The paper identifies PFKL interactors at specific interfaces and shows compartmentalization reduces interactions at interface 2.

Dark nanodiscs as a model membrane for evaluating membrane protein thermostability by differential scanning fluorimetry

This paper introduces a method using dark nanodiscs and nanoDSF to measure membrane protein thermostability, showing a biphasic unfolding pattern for DsbB with two distinct melting temperatures.

Elexacaftor/VX-445-mediated CFTR interactome remodeling reveals differential correction driven by mutation-specific translational dynamics

This study investigates how Elexacaftor/VX-445 affects CFTR interactome remodeling in response to specific mutations, revealing differential correction mechanisms.

Elucidation of Global Trends in the Effects of VX-661 and VX-445 on the Expression of Clinical CFTR Variants

This study compares the effects of VX-661 and VX-445 on 129 CFTR variants using deep mutational scanning, finding distinct patterns of expression rescue based on variant destabilization and binding pocket locations.

Distinct proteostasis states drive pharmacologic chaperone susceptibility for Cystic Fibrosis Transmembrane Conductance Regulator misfolding mutants

The paper investigates why different CFTR mutations respond variably to the pharmacological chaperone VX-809 by analyzing proteostasis interactions and degradation pathways.

Comparative multiplexed interactomics of SARS-CoV-2 and homologous coronavirus non-structural proteins identifies unique and shared host-cell dependencies

This study compares the interactomes of SARS-CoV-1, SARS-CoV-2, and hCoV-OC43 non-structural proteins to identify unique and shared host-cell dependencies, revealing potential therapeutic targets.

Upgraded molecular models of the human KCNQ1 potassium channel

This paper develops and validates structural models of human KCNQ1 potassium channels to understand mutation-induced dysfunction and guide drug design.