S. Ganguly

Consumption of human-relevant levels of sucrose-water rewires macronutrient uptake and utilization mechanisms in a tissue specific manner

This study shows that chronic sucrose water consumption in mice rewires tissue-specific molecular mechanisms, leading to systemic metabolic dysfunction including impaired glucose homeostasis and mitochondrial dysfunction.

Chandipura Virus forms cytoplasmic inclusion bodies through phase separation and proviral association of cellular protein Kinase R and stress granules protein TIA-1

This study shows Chandipura virus forms cytoplasmic inclusion bodies through phase separation involving PKR and TIA-1, evading antiviral stress granules and enhancing viral replication.

Rosetta 's Predictive Ability for Low-Affinity Ligand Binding in Fragment-Based Drug Discovery

This study evaluates RosettaLigand's ability to predict low-affinity ligand binding in fragment-based drug discovery using NMR data and finds it ranks binders with an AUC of 0.74.

Pseudocontact shift NMR data obtained from a non-canonical amino acid-linked lanthanide tag improves integral membrane protein structure prediction

The paper improves integral membrane protein structure prediction by integrating paramagnetic NMR restraints with RosettaNMR, achieving better model accuracy and sampling for DsbB.

Helminth egg derivatives as pro-regenerative immunotherapies

This study develops a regenerative immunotherapy using helminth-derived soluble egg antigen to promote tissue repair in multiple injury models.

First crystal structure of a non-canonical amino acid linked to a paramagnetic lanthanide tag facilitates protein structure determination using NMR-derived restraints

The paper presents the first crystal structure of a non-canonical amino acid linked to a paramagnetic lanthanide tag, showing how it improves NMR-derived structural modeling of proteins.

Leishmania Hijacks microRNA Import-Export Machinery of Infected Macrophage and Survives by Cross-Communicating Host miR-146a to Subjugate HuR and miR-122 in Neighbouring cells

This study shows Leishmania manipulates host miRNA transport to suppress inflammation and promote its survival by exporting miR-146a and inhibiting miR-122 in neighboring cells.

Age-associated Senescent - T Cell Signaling Promotes Type 3 Immunity that Inhibits Regenerative Response

This study shows that age-related senescent T cells promote type 3 immunity, which inhibits tissue repair, and that blocking this pathway improves healing in older animals.

Ergonomic risk factors and Work-related Musculoskeletal Disorders among Fireworks workers in West Bengal, India: A cross-sectional study

This study examines work-related musculoskeletal disorders among fireworks workers in West Bengal, finding high prevalence of lower back and upper limb disorders linked to awkward postures and age.

Morph-specific patterns of sex organ positions in species with style length polymorphism

The paper examines herkogamy and reciprocity in heterostylous species, finding higher herkogamy in short-styled morphs and variable reciprocity influenced by ecological factors.

Quantitative estimates of deciduousness in woody species from a seasonally dry tropical forest are related to leaf functional traits and the timing of leaf flush

The paper quantifies continuous variation in deciduousness among woody species in a seasonally dry tropical forest and links it to leaf traits and leaf flush timing.

Mapping the Promiscuous Binding Interface of HOX-A11 with KIX by Experimentally Guided in-silico docking

The paper identifies a promiscuous binding motif in HOXA11 IDR that interacts with two sites on the KIX domain of CBP through computational docking guided by experimental data.

Herkogamy but not reciprocity is a better predictor of legitimate pollen transfer and fruit set in Jasminum malabaricum, a self-compatible species with stigma-height dimorphism.

The study examines herkogamy and reciprocity in Jasminum malabaricum, finding herkogamy better predicts legitimate pollen transfer and fruit set than reciprocity.

Increased variation in sex organ positions can increase reciprocity and pollination success in heterostylous plant populations

This study introduces a new reciprocity index that accounts for intra-population variation in sex organ positions, showing that increased variation can enhance reciprocity and pollination success in heterostylous plants.