Actin fence therapy with exogenous V12Rac1 protects against Acute Lung Injury
G. A. Gusarova, S. Das, M. N. Islam, K. Westphalen, G. Jin, I. O. Shmarakov, L. Li, S. Bhattacharya, J. Bhattacharya
The paper shows that exogenous V12Rac1 enhances alveolar F-actin and prevents TNFR1 surge, reducing mortality in ALI caused by LPS or Pseudomonas aeruginosa.
bioRxiv · Jan 20, 2021Physiology