2-Cl-C.OXT-A Stimulates Contraction through the Suppression of Phosphodiesterase Activity in Human Induced Pluripotent Stem Cell-derived Cardiac Organoids
T. Kitsuka, M. Itoh, S. Amamoto, K.-i. Arai, J. Oyama, K. Node, S. Toda, S. Morita, T. Nishida, K. Nakayama
This study shows that COA-Cl increases cardiac organoid contraction by suppressing phosphodiesterase activity, independent of S1P1R and A1R.
bioRxiv · Feb 18, 2019Pharmacology & Toxicology