S. Morita

Combined blockade of CXCR4 and PD-1 enhances intratumoral dendritic cell activation and immune responses against HCC

This study shows that blocking CXCR4 and PD-1 together improves dendritic cell activation and immune responses against HCC in mouse models.

Liver fibrosis uncouples tumor control from survival after multikinase inhibitor immunotherapy in hepatocellular carcinoma

Liver fibrosis limits the survival benefit of multikinase inhibitor immunotherapy in hepatocellular carcinoma by promoting innate immune-mediated hepatotoxicity despite preserved tumor control.

Selective elimination of CD169+ macrophages in lymph nodes invaded by breast cancers

This study shows metastasized breast cancer cells eliminate CD169+ macrophages from lymph nodes, impairing anti-cancer immunity.

A stress sensor IRE1α is required for bacterial exotoxin-induced inflammasome activation in tissue-resident macrophages

The paper shows that IRE1α is essential for CTB and CT-induced IL-1β production in tissue-resident macrophages via NLRP3 and pyrin inflammasomes.

Forecasting fish recruitment using machine learning methods: A case study of arabesque greenling

This study uses machine learning to predict fish recruitment for Arabesque greenling, finding gradient boosting outperforms linear regression and random forest in accuracy.

Epigenetic mechanisms to propagate histone acetylation by p300/CBP

This study identifies how p300/CBP reads and writes histone acetylation to propagate epigenetic marks and activate gene transcription.

Evolution of horn length and lifting strength in the Japanese rhinoceros beetle Trypoxylus dichotomus

The paper studies the evolution of horn length and lifting strength in Trypoxylus dichotomus, showing independent increases in horn length in Northern and Southern lineages with mechanical trade-offs and compensatory changes.

Breast cancer progression and metastasis to lymph nodes reveals cancer cell plasticity and MHC class II-mediated immune regulation

This study identifies MHC class II expression in metastatic breast cancer cells and shows its role in immune evasion and tumor progression through IFN-gamma and JAK/STAT signaling.

Allosteric Inhibition of the T Cell Receptor by a Designed Membrane Ligand

This paper tests the allosteric model of TCR activation by designing a membrane ligand that inhibits TCR signaling, supporting the model and suggesting therapeutic applications.

Cancer tissue of origin constrains the growth and metabolism of metastases

This study shows that cancer tissue-of-origin influences the metabolism and growth preferences of both primary and metastatic tumors.

Delayed antigen-specific CD4+ T cell induction correlates with impaired immune responses to SARS-COV-2 mRNA vaccination in the elderly

The paper examines how delayed CD4+ T cell responses in the elderly correlate with reduced vaccine effectiveness and lower reactogenicity to SARS-CoV-2 mRNA vaccines.

Discrete LAT condensates encode antigen information from single pMHC:TCR binding events

The paper shows that LAT condensates form in response to pMHC:TCR binding events, with condensation probability linked to binding dwell time and a mutation affecting this process.

Height, but not binding epitope, affects the potency of synthetic TCR agonists

This paper investigates how the geometry of synthetic TCR agonists affects T cell activation, finding that ligand height, not epitope, determines potency.

2-Cl-C.OXT-A Stimulates Contraction through the Suppression of Phosphodiesterase Activity in Human Induced Pluripotent Stem Cell-derived Cardiac Organoids

This study shows that COA-Cl increases cardiac organoid contraction by suppressing phosphodiesterase activity, independent of S1P1R and A1R.

Multiple strategies for heat adaptation in rice endosperms revealed by on-site cell-specific analysis

This study reveals how rice endosperm cells adapt to heat stress through osmotic adjustments and nitrogen-dependent changes in organelle compartments, reducing chalkiness.