A stress-NRF2 response axis polarises tumor macrophages and undermines immunotherapy
Dominik J. Schaer, Nadja Schulthess-Lutz, Livio Baselgia, Kahrisan Kunasingam, Rok Humar, Kerstin Hansen, Florence Vallelian
This study identifies NRF2 as a stress-response axis that polarizes tumor macrophages into immunosuppressive, therapy-resistant states, and shows that inhibiting NRF2 can restore immunotherapy efficacy.
bioRxiv · Jul 2, 2025 · PreprintImmunology