Dominik J. Schaer

A stress-NRF2 response axis polarises tumor macrophages and undermines immunotherapy

This study identifies NRF2 as a stress-response axis that polarizes tumor macrophages into immunosuppressive, therapy-resistant states, and shows that inhibiting NRF2 can restore immunotherapy efficacy.

Transcriptomic profiling of an ex vivo model of erythropoiesis uncovers potential genes and pathways involved into the pathogenesis of sickle cell disease

The paper identifies differentially expressed genes and enriched pathways in SCD patient-derived erythroid cells compared to healthy controls, validated in a mouse model.

Blood oxygenation-level dependent cerebrovascular reactivity imaging as strategy to monitor CSF-hemoglobin toxicity

This study assesses the toxic effects of CSF-hemoglobin on cerebral blood flow and autoregulation using BOLD-CVR imaging and tests the protective role of haptoglobin in a sheep model.

MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and edema in intracerebral hemorrhage

This study identifies a biphasic inflammatory response after intracerebral hemorrhage, with an early MyD88-TLR4-dependent activation of the choroid plexus preceding secondary inflammation and leukocyte infiltration.