Florence Vallelian

This study identifies NRF2 as a stress-response axis that polarizes tumor macrophages into immunosuppressive, therapy-resistant states, and shows that inhibiting NRF2 can restore immunotherapy efficacy.

The paper identifies differentially expressed genes and enriched pathways in SCD patient-derived erythroid cells compared to healthy controls, validated in a mouse model.

This study identifies a biphasic inflammatory response after intracerebral hemorrhage, with an early MyD88-TLR4-dependent activation of the choroid plexus preceding secondary inflammation and leukocyte infiltration.