Viral Insulin/IGF-like Peptides Selectively Activate Host Insulin/IGF Signaling pathways during Grouper Iridovirus Infection
Aurélien Chuard, Kalaimagal Nesarajah, Khadija Danazumi, Kaitlin Reiners, Zhang Fa, Lev Levintov, Harish Vashisth, Richard D. DiMarchi, Emrah Altındiş
This study identifies GIV-VILP as a viral mimic of host insulin/IGF-1 that selectively activates the Akt/PI3K pathway during infection, enhancing viral replication.
bioRxiv · Jun 13, 2024 · PreprintMicrobiology