FDA-approved drug library screen identifies antidepressants, antimicrobials, anti-COPD, and anti-CVD agents as blockers of NLRP3 inflammasome and sepsis in a sex-dependent manner.
Kara Timinski, Ashutosh Prince, Kalash Neupane, Swati Sharma, Nilam Bhandari, Mariam R. Khan, Yavar Shiravand, C. Alicia Traughber, Zackery Raquepaw, Kailash Gulshan
The paper screens FDA-approved drugs to identify those that block NLRP3 inflammasome activation and sepsis, with sex-dependent efficacy.
bioRxiv · Jul 29, 2026 · PreprintCell Biology