Targeting FUS-ALS aggregation with Proteasome Inhibitors
Amal Younis, Kanar Yassen, Kinneret Rozales, Tahani Kadah, Naseeb Saida, Anatoly Meller, Joyeeta Dutta Hazra, Ronit Heinrich, Flonia Levy‐Adam, Shai Berlin, Reut Shalgi
This study shows proteasome inhibitors reduce FUS aggregation in ALS models through HSF1-dependent transcriptional mechanisms, suggesting a potential therapeutic strategy for ALS-FUS.
bioRxiv · Sep 17, 2024 · PreprintMolecular Biology