Reut Shalgi

Chaperone isoform and interactome mapping reveals functional diversification of DNAJA2-DNAJA4 complexes via stress-regulated isoforms

The paper maps isoforms and interactions of the HSP70 network, identifying stress-regulated isoforms that form hetero-complexes and modulate TDP-43 aggregation.

Targeting FUS-ALS aggregation with Proteasome Inhibitors

This study shows proteasome inhibitors reduce FUS aggregation in ALS models through HSF1-dependent transcriptional mechanisms, suggesting a potential therapeutic strategy for ALS-FUS.

Stress-induced transcriptional readthrough into neighboring genes is linked to intron retention

The paper identifies stress-induced readthrough transcription into downstream genes (read-in) and links it to increased intron retention in mouse fibroblasts under stress conditions.

Differential roles for DNAJ isoforms in HTT-polyQ and mutant FUS aggregation modulation revealed by chaperone network screens

Cellular proteostasis decline in human senescence

This study shows proteostasis decline in human senescence through transcriptome-wide analysis, revealing impaired transcriptional responses and proteasome function.

Fluorescent polysome profiling reveals stress-mediated regulation of HSPA14-ribosome interactions

The paper introduces fluorescent polysome profiling to study ribosome-associated factors, showing increased HSPA14-polysome association under heat shock.

Widespread PERK-dependent repression of ER targets in response to ER stress

The paper investigates PERK's role in ER stress response by analyzing gene expression in PERK -/- MEFs, finding widespread PERK-dependent repression of ER-targeted genes.