Shai Berlin

Epigenetic inheritance of complex learning abilities in the mammalian brain

This study shows that complex learning abilities can be inherited through epigenetic modifications in the mammalian brain, as offspring of trained rodents exhibit enhanced neuronal excitability and DNA methylation changes.

Targeting FUS-ALS aggregation with Proteasome Inhibitors

This study shows proteasome inhibitors reduce FUS aggregation in ALS models through HSF1-dependent transcriptional mechanisms, suggesting a potential therapeutic strategy for ALS-FUS.

A novel polycistronic method tailored for engineering split GECIs

The paper demonstrates a method using stop-codons to enable polycistronic expression in eukaryotic cells, leading to the development of split-GECIs for monitoring cellular processes.

Two extreme Loss-of-Function GRIN2B-mutations are detrimental to tri-heteromeric NMDAR-function, but rescued by pregnanolone-sulfate

This study examines two GRIN2B mutations in di- and tri-heteromeric NMDARs, showing they impair function but are rescued by pregnanolone-sulfate.

Differential roles for DNAJ isoforms in HTT-polyQ and mutant FUS aggregation modulation revealed by chaperone network screens