Loss of presenilin 2 function age-dependently increases susceptibility to kainate-induced acute seizures and blunts hippocampal kainate-type glutamate receptor expression
Larissa Robinson‐Cooper, Stephanie Davidson, Rami Koutoubi, Kangni Zhang, Hannah Park, Melissa L. Barker‐Haliski
This study shows that loss of presenilin 2 function increases seizure susceptibility in young mice but not in aged mice, and reduces GluK5 expression in aged PSEN2 knockout mice.
Experimental Neurology · Dec 10, 2025Peer-reviewedNeuroscience