Stephanie Davidson

A Humanized Mouse Model of DRPLA Recapitulates Epilepsy and Demonstrates Antisense Oligonucleotide-Mediated Disease Modification

This study uses a humanized mouse model to show that antisense oligonucleotides reduce seizure activity and mortality in DRPLA.

Loss of presenilin 2 function age-dependently increases susceptibility to kainate-induced acute seizures and blunts hippocampal kainate-type glutamate receptor expression

This study shows that loss of presenilin 2 function increases seizure susceptibility in young mice but not in aged mice, and reduces GluK5 expression in aged PSEN2 knockout mice.

Intestinal Dysbiosis Alters Acute Seizure Burden and Antiseizure Medicine Activity in the Theiler's Virus Model of Encephalitis

This study shows that antibiotic-induced gut dysbiosis alters seizure burden and carbamazepine anticonvulsant activity in a Theiler's virus encephalitis model without affecting drug plasma concentrations.

Alzheimer's disease-associated genotypes differentially influence chronic evoked seizure outcomes and antiseizure medicine activity in aged mice

This study investigates how Alzheimer's disease-associated genotypes affect seizure outcomes and antiseizure medication efficacy in aged mice, finding differential responses to specific drugs.

Diet composition and sterilization modifies intestinal microbiome diversity and burden of Theiler's virus infection-induced acute seizures

This study examines how diet and sterilization affect gut microbiome diversity and acute seizure incidence in TMEV-infected mice, finding diet impacts seizure frequency and behavioral outcomes.

Chronic evoked seizures in young pre-symptomatic APP/PS1 mice induce serotonin changes and accelerate onset on Alzheimer's disease-related neurpathology

This study shows that chronic seizures in pre-symptomatic APP/PS1 mice worsen Alzheimer's disease-related pathology and serotonin pathway disruptions without amyloid β plaque formation.