Determinants of cysteine coverage by chemoproteomics
Ioannis G. Riziotis, Harry Wilders, Andrea Cairoli, Hugues Lambert, Jamie Dark, George S. Biggs, Emma E. Cawood, William J. McCarthy, Luke Nightingale, María Paula Magariños, Mike Gavrielides, Karen Ambrose, Amy Strange, Mark J. Skehel, Simon J. Boulton, , Jacob T. Bush
This study identifies factors governing cysteine detection in chemoproteomics using machine learning and statistical filtering, showing that peptide properties and abundance are key determinants.
bioRxiv · Oct 19, 2026 · PreprintBioinformatics