William J. McCarthy

This study identifies factors governing cysteine detection in chemoproteomics using machine learning and statistical filtering, showing that peptide properties and abundance are key determinants.

The paper identifies a covalent fragment inhibitor of TYMS that selectively kills ATRX-deficient cells through replication stress.

This paper develops a label-free chemoproteomics platform to profile cysteine-reactive fragments, identifying over 400 ligand-protein interactions in two cell lines.