Simon J. Boulton

This study identifies factors governing cysteine detection in chemoproteomics using machine learning and statistical filtering, showing that peptide properties and abundance are key determinants.

This study shows TRF2 mediates force-resistant tethering of telomeric DNA repeats, which may be a step in T-loop formation.

The paper shows MEN1 deficiency reduces ferroptosis by altering ACSL1 and GPX4 levels, with selenite affecting resistance.

This study identifies distinct roles of ATRX in safeguarding genome and telomere integrity through interactions with CST and 9-1-1 complexes, revealing context-dependent mechanisms.

The paper identifies a covalent fragment inhibitor of TYMS that selectively kills ATRX-deficient cells through replication stress.

This study identifies hypertranscription as a vulnerability in H3K27M-driven diffuse midline gliomas, showing ATR inhibition effectively targets this feature in preclinical models.

This paper identifies SLFN11's role in preventing alternative lengthening of telomeres by eliminating ATRX-deficient cells during telomere crisis, contributing to chemoresistance in cancer.

This paper develops a label-free chemoproteomics platform to profile cysteine-reactive fragments, identifying over 400 ligand-protein interactions in two cell lines.

This paper shows that HLTF has two roles in managing G4s: preventing their accumulation and slowing replication forks to maintain genome stability.

This paper shows HIV-1 Vpr causes separate G2 and M phase cell cycle arrests that activate distinct DNA damage pathways, with implications for early HIV replication.

This study identifies APE2 nuclease as a critical factor for MMEJ repair, showing its role in telomere fusion and DNA repair reporter assays.

The paper investigates the roles of RTEL-1 and DNA polymerase theta in subtelomeric DNA synthesis and telomere fusion in C. elegans, finding they promote these processes through distinct mechanisms.

This study shows that satellite repeat transcripts in mouse ESCs drive heterochromatin condensates, which are crucial for chromosome stability and nuclear organization.

This study shows TLK1/2 activity protects replication forks, contributes to chromatin silencing, and suppresses innate immune responses, with implications for immune evasion in chromosomally unstable cancers.

The paper analyzes mutational spectra in C. elegans DNA repair mutants to identify how different repair pathways affect mutagenesis in germ cells.

This study shows SMCHD1 is required for ATM-dependent DNA damage signaling and repair of uncapped telomeres, with its depletion reducing telomere fusions in TRF2-depleted cells.

The paper maps oxidative DNA damage and repair across the genome, revealing regioselective protection of regulatory and coding regions from mutations.