Codon Deoptimization of Multispecific Biologics Reduces Mispairing During Transient Mammalian Protein Expression
Timothy Z. Chang, Weijun Ma, Jane Guo, Jiali Hu, Kalie A. Mix, Yi Tang, Karen Wong, Eva Bric-Furlong, Amanda Lennon, Brian E. Hall, Dietmar Hoffmann
This study shows that deoptimizing serine codons in multispecific biologics reduces mispairing and increases protein purity during transient mammalian expression.
Frontiers in Bioengineering and Biotechnology · Feb 26, 2026Peer-reviewedBioengineering