Author

Timothy Z. Chang

Harvard UniversityORCID 0000-0002-5620-6062Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Colin MolloyiD· 2 shared Debora S. MarksiD· 2 shared Erika J. Olson· 2 shared H. Sloane Weiss· 2 shared Jeffrey C. WayiD· 2 shared John I. GlassiD· 2 shared Nathan J. RollinsiD· 2 shared Pamela A. SilveriD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSystems Biology

Colin MolloyORCID

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3 papers

Recent·Most cited

BioengineeringFrontiers in Bioengineering and BiotechnologyPeer-reviewedFeb 26, 2026

Codon Deoptimization of Multispecific Biologics Reduces Mispairing During Transient Mammalian Protein Expression

Timothy Z. Chang, Weijun Ma, Jane Guo…·Dietmar Hoffmann

This study shows that deoptimizing serine codons in multispecific biologics reduces mispairing and increases protein purity during transient mammalian expression.

DOI 10.3389/fbioe.2026.1783067

humanproteomics

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Systems BiologymSystemsPeer-reviewedMar 23, 2022

High content screening and computational prediction reveal viral genes that suppress innate immune response

Tai L. Ng, Erika J. Olson, Tae Yeon Yoo…·Pamela A. Silver

The paper develops a high-content assay to identify viral genes that suppress innate immunity and validates known and novel immune suppressors from various viral families.

9 citations

humanexperimental assay

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Systems BiologybioRxivPreprintMar 2, 2021

High-content screening of coronavirus genes for innate immune suppression revealsenhanced potency of SARS-CoV-2 proteins

Erika J. Olson, David Brown, Timothy Z. Chang…·Pamela A. Silver

The paper screens coronavirus proteins for innate immune suppression, finding SARS-CoV-2 proteins are more potent immune suppressors than other coronaviruses.

4 citations

humanproteomics

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