Human iPSC-derived liver organoids model multicellular tissue responses and therapeutic rescue in Wolman disease
Davide Selvestrel, Caterina Da Rodda, Beatrice Anfuso, Marine Laurent, Annamaria Antona, Alessia Mattivi, Suresh Velnati, Karin Hofmann, Luciano Conti, Deborah Bonazza, Fabrizio Zanconati, Manuela Mastronardi, Nicolò de Manzini, Natalia Rosso, Rebecca Bertolio, , Giovanni Sorrentino
This study uses human liver organoids to model Wolman disease, showing multicellular interactions drive disease features and therapeutic responses.
bioRxiv · Jul 10, 2026 · PreprintPathology