Luciano Conti

Functional validation of allele-specific LMNB1 silencing in patient-derived astrocytes as a therapeutic option for Autosomal Dominant Leukodystrophy

This study validates allele-specific LMNB1 silencing in patient-derived astrocytes as a therapeutic approach for ADLD by showing restored physiological levels and functional improvements.

Human iPSC-derived liver organoids model multicellular tissue responses and therapeutic rescue in Wolman disease

This study uses human liver organoids to model Wolman disease, showing multicellular interactions drive disease features and therapeutic responses.

ARHGEF6-dependent cytoskeletal regulation underlies a conserved program of forebrain interneuron development

This study identifies ARHGEF6's role in forebrain interneuron development across species, showing its impact on migration, survival, and circuit formation.

Generation and benchmarking of a collection of hiPSC lines from Schizophrenia Patients with Diverse Clinical Profiles

The paper generates and validates a collection of hiPSC lines from Schizophrenia patients with diverse clinical profiles to model disease-specific neural phenotypes and develop targeted therapies.

Defective linear and circular RNAs biogenesis in Huntington's disease: CAG repeat expansion hijacks neuronal splicing

The paper shows that CAG repeat expansion in Huntington's disease disrupts splicing, reducing circular RNA production and affecting neural progenitors and striatum before symptoms appear.

Inducible alpha-synuclein overexpression affects human Neural Stem Cells behavior

This paper develops a conditional human neural stem cell model to study alpha-synuclein effects on cell behavior and toxicity in Parkinson's disease.