CDDO-Imidazole regulates RBC alloimmunization to the KEL antigen by activating Nrf2
Che‐Yu Chang, Rosario Hernández‐Armengol, Kausik Paul, Juneyoung Lee, Karina Nance, Tomohiro Shibata, Peibin Yue, Christian Stehlik, David R. Gibb
This study shows that CDDO-Im, an Nrf2 activator, reduces RBC alloimmunization to the KEL antigen by suppressing IFNβ-stimulated gene expression and promoting RBC recovery in mice.
bioRxiv · Apr 3, 2025 · PreprintImmunology