Resolving within-host malaria parasite diversity using single-cell sequencing
Standwell C. Nkhoma, Simon G. Trevino, Karla M. Gorena, Shalini Nair, Stanley Khoswe, Catherine Jett, Roy Garcia, Benjamin J. Daniel, Aliou Dia, Dianne Janette Terlouw, Stephen Andrew Ward, Timothy J. C. Anderson, Ian H. Cheeseman
This study uses single-cell sequencing to analyze within-host diversity of Plasmodium falciparum in malaria patients, revealing up to seventeen unique lineages per patient and suggesting co-transmission from a single mosquito is more common than superinfection.
bioRxiv · Aug 13, 2018 · PreprintGenetics