Catherine Jett

This paper develops a method to efficiently profile the transcriptome of the malaria parasite Plasmodium falciparum across its erythrocytic cycle using flow sorting.

The paper tracks genomic diversity in Plasmodium falciparum during in vitro cultivation, showing increased growth rate and clonal interference over 84 asexual cycles.

The paper reports two new genetic crosses of Plasmodium falciparum in humanized mice, showing significant variation in marker segregation and demonstrating improved power for genetic mapping of malaria traits.

This study uses single-cell sequencing to analyze within-host diversity of Plasmodium falciparum in malaria patients, revealing up to seventeen unique lineages per patient and suggesting co-transmission from a single mosquito is more common than superinfection.