End-To-End, Fully Automated Manufacturing of Hematopoietic Stem and Progenitor Cell Therapy Via CCR5-Targeted Integration
Jack M.P. Castelli, Nowah Kokou Apeadoufia Afangbedji, Sofia E. Luna, Freja K. Ekman, Dmitry Malkov, Karthik Shastry, Victor Rocha, Arpit Batish, Anna Sahakyan, Julie Fang, Zhou Li, Kayla Ruggiero, Jessica Fioravanti, Fabrizia Urbinati, Matthew Hebden Porteus
This paper demonstrates an automated, high-throughput platform for manufacturing gene-edited hematopoietic stem and progenitor cells (geHSPCs) with preserved function and in vivo engraftment capacity.
bioRxiv · Oct 30, 2026 · PreprintGenetics