Jack M.P. Castelli

This paper demonstrates an automated, high-throughput platform for manufacturing gene-edited hematopoietic stem and progenitor cells (geHSPCs) with preserved function and in vivo engraftment capacity.

This study shows non-viral gene editing in primate hematopoietic stem cells can produce anti-HIV antibodies in vivo with detectable titers.

This paper improves CRISPR-AuNP delivery by optimizing Cas9 RNP loading and nanoparticle surface chemistry, achieving higher RNP loading and uptake in HSPCs but with limited endosomal escape.

The paper discovers a pro-nematicide scaffold, Cyprocide, that selectively kills diverse plant-parasitic nematodes through P450 enzyme activation, offering a potential solution for sustainable nematode management.