Author

Karthik Srinivasan

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Systems Biology· 2 Cancer Biology· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:metagenomics· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Germán PlataiD· 2 shared Purushottam D. DixitiD· 2 shared Alexandra E. GouldiD· 1 shared Alison CameroniD· 1 shared Amirshayan Chadeganipour· 1 shared Ashlee D. BrunaughiD· 1 shared Bhanuz DechayontiD· 1 shared Blanche C. IpiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersEcology

Germán PlataORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Dynamic inositol pyrophosphate synthesis is a targetable therapeutic opportunity in ovarian cancer.

Daniel P. Bondeson, David Husselbee, Saoirse Hanbury, Amirshayan Chadeganipour, Gabriel Mesa, Alison Cameron, Janhavi Y. Sawant, Carly R. Langan, Tuhina Bhattacharya, YuhJong Liu, Hajer Siala, Erin M Swanson, Mustafa Kocak, Karthik Srinivasan, Blanche C. Ip, , Todd R. Golub

This study evaluates strategies to inhibit XPR1 in ovarian cancer, showing that IP6K inhibitors effectively mimic XPR1 inhibition by blocking phosphate efflux and reducing tumor burden in xenograft models.

bioRxiv · Aug 26, 2026 · PreprintCancer Biology

Transfer learning predicts species-specific drug interactions in emerging pathogens

Carolina H. Chung, David C. Chang, Nicole M. Rhoads, Prajna Lalitha, Gunasekaran Rameshkumar, Rajarathinam Karpagam, Manojkumar Vimaladevi, Madeline R. Shay, Karthik Srinivasan, Mercy A. Okezue, Bhanuz Dechayont, Ashlee D. Brunaugh, Sriram Chandrasekaran

The paper develops a transfer learning framework to predict drug interactions for under-studied pathogens and validates synergistic combinations against antibiotic-resistant bacteria.

Cell Reports Methods · Jul 7, 2026Peer-reviewedSystems Biology

Niche dimensionality drives microbial community structure

Karthik Srinivasan, Germán Plata, Purushottam D. Dixit

The paper infers microbial niche dimensionality from abundance data and shows it correlates with environmental complexity, competition, and biodiversity in human gut microbiomes.

bioRxiv · Nov 2, 2025 · PreprintEcology

Designing host-associated microbiomes using the consumer/resource model

Germán Plata, Karthik Srinivasan, Madan Krishnamurthy, Lukas Herron, Purushottam D. Dixit

This paper introduces a generative model based on the consumer/resource framework to design host-associated microbiomes that correspond to desired host phenotypes and vice versa.

mSystems · Dec 9, 2024Peer-reviewedSystems Biology