Author

YuhJong Liu

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:genetic perturbation / CRISPR· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

John G. DoenchiD· 3 shared Mustafa KocakiD· 3 shared Todd R. GolubiD· 3 shared Blanche C. IpiD· 2 shared Daniel P. BondesoniD· 2 shared Jennifer A. RothiD· 2 shared Aidan Cruickshank· 1 shared Alexandra E. GouldiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

John G. DoenchORCID

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3 papers

Recent·Most cited

Dynamic inositol pyrophosphate synthesis is a targetable therapeutic opportunity in ovarian cancer.

Daniel P. Bondeson, David Husselbee, Saoirse Hanbury, Amirshayan Chadeganipour, Gabriel Mesa, Alison Cameron, Janhavi Y. Sawant, Carly R. Langan, Tuhina Bhattacharya, YuhJong Liu, Hajer Siala, Erin M Swanson, Mustafa Kocak, Karthik Srinivasan, Blanche C. Ip, , Todd R. Golub

This study evaluates strategies to inhibit XPR1 in ovarian cancer, showing that IP6K inhibitors effectively mimic XPR1 inhibition by blocking phosphate efflux and reducing tumor burden in xenograft models.

bioRxiv · Aug 26, 2026 · PreprintCancer Biology

Discovery of chromatin-based determinants of azacytidine and decitabine anti-cancer activity

Rishi V. Puram, Qiangzong Yin, YuhJong Liu, Justine C. Rutter, Daniel P. Bondeson, Maria C. Saberi, Lisa A. Miller, Michael Yifei Du, Khanh Nguyen, Donovan L. Batzli, Hilina B. Woldemichael, Christian Taeger, Anna Goldstein, Ming Y. Chu, Qi Guo, , Todd R. Golub

This study identifies DNA hypomethylation, not DNA damage, as the primary mechanism of azacytidine and decitabine anti-cancer activity, linking it to chromatin regulators like USP48.

bioRxiv · Jul 29, 2025 · PreprintCancer Biology

Sialylated CD43 is a glyco-immune checkpoint for macrophage phagocytosis

Jooho Chung, Mounica Vallurupalli, Sarah Noel, Gail Schor, YuhJong Liu, Celeste Nobrega, Jonathan Perera, Ewa Wrona, Margaret Hu, Yunkang Lin, David Wei Wu, Maria Saberi, Ilario Scapozza, Aidan Cruickshank, Elliot C. Woods, , Robert T. Manguso

The paper identifies CD43 as a glyco-immune checkpoint that inhibits human macrophage phagocytosis, showing that O-linked glycosylation and sialylation pathways regulate this process in AML.

bioRxiv · May 5, 2025 · PreprintCancer Biology