DILP8 serves as a mature follicle sensor to prevent excessive accumulation of maturefollicles in Drosophila ovaries and oocyte aging.
Rebecca Oramas, Katarina Yacuk, Stella E. Cho, Natalie R Aloisio, Jianjun Sun
This study identifies DILP8 as a sensor for mature follicle accumulation in Drosophila ovaries, preventing excessive follicles and maintaining oocyte quality through the Lgr3 receptor.
bioRxiv · Apr 2, 2025 · PreprintPhysiology