Pharmacological inhibition of Fms-like kinase 3 (FLT3) promotes neuronal maturation and suppresses seizure in a mouse model
Kate Cruite, Madeline Moore, Michael D. Gallagher, Emanuel M. Coleman, Yuqin Yin, Shuqi Lin, Ellie Shahbo, Tenzin Lungjangwa, Volker Hovestadt, Rudolf Jaenisch, Jamie L. Maguire, Xin Tang
This study shows that FLT3 inhibition promotes neuronal maturation and reduces seizures in a mouse model by upregulating KCC2 and reducing neuroinflammation.
bioRxiv · Oct 2, 2024 · PreprintNeuroscience