Jamie L. Maguire

This study shows that neurosteroid-based treatment improves network and behavioral deficits in postpartum mice by restoring theta oscillations and maternal behavior.

The paper shows that specific BLA neurons are recruited by oscillatory states to drive valence-related behaviors.

This study uses Motion Sequencing combined with a novel analysis pipeline to identify repetitive behaviors in epileptic mice and shows that carbamazepine partially rescues these behaviors.

This study shows that chronic alcohol exposure impairs neurosteroid production and that enhancing neurosteroid levels can affect alcohol consumption and withdrawal behaviors.

This study identifies a PV-driven oscillatory switch in the amygdala that governs valence assignment through noradrenergic modulation.

The paper shows that NE activates CCK interneurons in the BLA to generate rhythmic inhibitory input, reducing fear memory through enhanced theta oscillations.

This study shows that hyperreactive stress circuits in mice increase time-dependent SUDEP susceptibility through exaggerated autonomic reflexes following seizure induction.

This study shows that Candida albicans colonization reduces ethanol consumption and alters dopamine signaling and behavioral responses in mice through prostaglandin E2.

This study shows that early life stress impairs VTA coordination of BLA network and behavioral states by weakening dopamine signaling between VTA and BLA, leading to increased social avoidance.

This study shows that early life stress affects epilepsy outcomes in mice, with sex-dependent effects on seizure susceptibility and mortality.

This study shows that FLT3 inhibition promotes neuronal maturation and reduces seizures in a mouse model by upregulating KCC2 and reducing neuroinflammation.

This study investigates sex-dependent effects of early life stress on network and behavioral states in mice, finding sex-specific alterations in physiology and network activity linked to stress reactivity.

This study shows that both direct and witnessed trauma reduce allopregnanolone levels and impair fear regulation in mice, suggesting neurosteroid deficits contribute to PTSD-like behaviors.

This study shows that parvalbumin interneurons in the basolateral amygdala coordinate oscillations that drive reward behaviors and are necessary for reward value processing.

This study shows that the p97 R155H mutation impairs lysophagy in motor neurons, leading to lysosomal dysfunction and reduced viability.

This study shows that loss of PV interneurons in the BLA of chronically epileptic mice leads to altered network and behavioral states, contributing to comorbid anxiety and epilepsy.

The paper develops a semi-automated seizure detection system using interpretable machine learning models and an open-source tool for improved efficiency and accuracy.

The paper shows that brief tofacitinib treatment suppresses seizures and reverses cognitive deficits in chronic epilepsy by targeting a resurgent JAK/STAT pathway activation.

This study shows that prior positive or negative experiences alter the activity of specific BLA neurons, affecting valence processing by biasing information routing.

This study shows that Sema4D treatment reduces seizure susceptibility and restores benzodiazepine sensitivity in a mouse model of Status Epilepticus.

The paper shows that BLA network states modulated by {delta} subunit-containing GABAA receptors on PV interneurons predict voluntary alcohol intake.

This study shows chronic stress impairs endogenous neurosteroid signaling in the BLA, leading to behavioral deficits, and suggests targeting neurosteroidogenesis could be a new treatment for mood disorders.

This study shows alcohol modulates BLA network states differently in male and female mice, involving δ-GABAARs on PV interneurons, linking alcohol use and anxiety behaviors.

This study shows that HPA axis dysfunction in a mouse model increases SUDEP risk and worsens epilepsy outcomes, with potential implications for psychiatric comorbidities.

The paper investigates how neuromodulation of parvalbumin interneurons in the basolateral amygdala affects network and behavioral states during fear expression.

This study shows allopregnanolone modulates oscillatory states in the basolateral amygdala through delta-containing GABAA receptors, contributing to antidepressant effects.

This study shows that GRF1 in CRF cells of the hypothalamus influences the stress response in early adolescent female mice, reducing CORT levels and anxiolytic effects after repeated stress.