Michael D. Gallagher

This study evaluates inducible transgenic systems in human pluripotent stem cells and differentiated cells, identifying a small molecule-mediated splicing switch that enables tunable transgene expression without protein tags.

The paper identifies cis and trans gene regulatory mechanisms in microglia linked to multiple sclerosis risk SNPs using computational and CRISPR perturbation approaches.

This study shows that FLT3 inhibition promotes neuronal maturation and reduces seizures in a mouse model by upregulating KCC2 and reducing neuroinflammation.

The paper identifies a causal variant near TMEM106B that alters chromatin architecture and gene expression, linking it to frontotemporal lobar degeneration and neurodegenerative disease risk.