Hypoxia-inducible factor 2-alpha promotes fitness of cytokine-activated human natural killer cells
H. Alex Feldman, Andrew VonHandorf, Kate E Alianiello, Krista L English, Seth D Reighard, Hermine I Brunner, Leah C Kottyan, Matthew T Weirauch, Kenneth M Kaufman, Stephen N Waggoner
This study identifies HIF-2 as a critical factor for the survival of cytokine-activated human NK cells, showing it is induced by IL-2/IL-15 and not hypoxia, and its inhibition reduces NK cell viability.
bioRxiv · Nov 6, 2026 · PreprintImmunology